A tribute to the mice (meeting)

A tribute to the mouse (top) www.thebeijingnews.com · 2006-12-11 10: 53: 08 · Source: Beijing News why biological experiments like selected mice? first just for their body size and compact, omnivorous and fecundity. These little guys gene number comparable with others, cells, organs and even behavior and we are very much — rat even like a person as a result of pressure and tension. At the beginning of last century, geneticists from pet market bought the mouse, hybrid, and observe the legitimate child of fur color, verify correctness Mendel's law. After that, the psychologist who was once a popular walking rat, exciting to do training mice walk the labyrinth. The last century, for drug addiction research scholars suddenly discovered that there's a variety of convenient, mouse and drugs entangled in this way. Career addict who would like to take advantage of the mice to study drug addiction, the priority is to prove that they talk to people, have the potential to become a drug addict. He was a pioneer, we know, put a pedal, stepped on a hit, drug injection into its body. If the drug is injected cocaine or heroin, a week, and from pedal frequency, it has fallen in love with this psychedelic movement. However, a priori not scientific attitude, also no one dared to package ticket it and a human drug users have been able to put themselves in between. To detect this mouse is not a drug addict, you have to see it have a painful withdrawal reaction. Thus, the experiment personnel came on the drug into a saline, bad mice are forced to carry out compulsory treatment. At first, it'll patiently walking away, after a few days, because the habit of disappointment, Stampede frequency reduced gradually, it has forgotten their used to be a mouse only if a drug addict, walked through the pedal as well as a cloud of memory, as if this pedal Qing dynasty had never bring it Rapture. All the reactions of drug addicts with human presumptuous in full compliance with, scientists began to study a fundamental question: what makes mouse addiction? 1960s, neuro-biologists try to cages of mice were injected a blocking dopamine drugs after the drug into normal saline, mice were no longer pedal madly. Today we know that the experiment was blocking dopamine produced drug dependence of critical material, its daily work as a neurotransmitter in the brain to pass information in, the effect is felt with the happiness of mankind. At this point, there is a problem in my brain, why drug users their labors rate high? this problem to get the mice to study, and have no imagination. A human on the drug addicts, might come from a former companions of a phone call: "Hey, man, do you want out of it. " But on mouse, how to hook up the desire for drugs, and quantification of this desire, big trouble. The breakup, life is not happy drug users are often more likely to relapse — painful stimulation may be raised relapse of a good approach, researchers from this inspired on the withdrawal of the cage to shock in rats. Sure, the mouse quickly think of themselves once only, on drug addict's craving to fire out of the landmark action is to step on the pedal, pedal frequency in this can be used as a craving severity of measurements. Psychological in addition to the aspirations of electric shock, you can also use conditioning methods cause the mouse's craving. Each time the mouse injecting drug, is in the cage into the sound or light stimulation. When the mouse after withdrawal of the scene in the past, brought its desire to ... Lights out, voice sounded like Jabalpur Pavlov's dog, mice Shua, suddenly raised strong desire for drugs, and painful stimulation response. You now have a relapse of quantitative indicators, let's take a look at how mice relapse, the drug after imposition of stimulation lead to mouse pedal frequency changes draw curves, where you can find the mice were drugcraving will gradually as time goes by. A-average life expectancy of approximately 2 and a half years of experimental rat, cocaine withdrawal, the first day of the craving for drugs, and then rise, half a year later began to decline, but still higher than the first day. Research has shown that the drug is a biological basis of chronic recurrent disease that has nothing to do with the personal willpower. While further research findings, and relapse of neural circuits and known memory storage related circuit have many similarities, is involved in brain regions more and more, things become more complicated. Fortunately, scientists are beginning to grasp a few silk thread, that is to pass information in the brain neurotransmitters. And drug addiction-related neurotransmitters, in addition to our already familiar dopamine, glutamate, and GABA has become the new hot research topics. While the prospect is unknown, but a drug abuse research institutions in charge of it at least gives us more confidence in the future, "the next five to 10 years on drug abuse treatment method is bound and today. " □ Cirsii (Beijing life sciences master 's)