Biochips: future applications as computer chip

Biochips: future applications like computer chip www.thebeijingnews.com · 2006-12-11 11: 46: 40 · Source: Beijing News what is bio-chip? perhaps a lot of people haven't heard of this thing, maybe a lot of people will take it and electronic chip, such as semiconductor chips. We can know that the bio-chip in China, has really did appear a certain scale of cutting-edge research team. Although it away from the daily lives of ordinary people is far from, but it can be expected in the future, bio-chip as the technology matures, and as today's computer chip, a blowout-appear in people's lives. With the US biotechnology co., Ltd. and other enterprises and dependent universities 863 plan promotion, our nation in creature chip patent or the application in the field of scientific research, has formed a certain scale. The internal structure of biochips. Like the cloth like colorful biochip. Core concepts what is integrated is the biochip? simply, bio-chip is a piece of glass, silicon chip, materials such as nylon membrane on biological samples, and then from one instrument to collect signals, use a computer analysis of the data results. People could easily put the biochip linked with electronic chip, in fact, bio-chips and electronic chip inextricably linked, but two completely different things. The concept of "chip from the integration of concepts such as electronic chip means big things into small things. " China's first bio-chip manufacturer, Boao biological field of proteomics, Chief Scientist, Dr. Yang Wei: flat," bio-chip integration, but also is the integration of biological materials. " In the current common biological detection, General containers are test tubes, as we have seen in a chemical laboratory and test these biochips, concentrated to a little template. Like a laboratory, the biochip check blood glucose, protein, enzymes, and is based on the same principles of biological reactions. "Chip is only a carrier. Do something, detection, or biologist. Why bio-chip is a carrier of the platform. "Yang Wei: Ping said. This platform is there are many kinds of materials such as Silicon and glass, film (cellulose film), there are three dimensional structure of the polymer, the platform is pinged with various biological materials. "Like a chessboard," Shanghai biochip co., Ltd. gene Deputy General Manager of the mean pine said, "such as 19 rows by 19 column, very neat, orderly arranged in rows and columns, each with different biological materials, such as nucleic acid solution, they each point as a tube, a different response. "" In fact, the bio-chip is not the same as the electronic chip, just borrow the concept, its original name was ' DNA Microarray ', because it is at the intersection of the columns. "That is, to a large lab takes a more tube of reaction, it is moved to a chip at the same time. And electronic chip is far and near, in fact, the electronic chip and biochip has both far and near. "They are the same is with very small components, a large amount of storage, input and output. " Yang Hongbo says. The so-called bio-chip output is in square centimeters large chip, using specially crafted scanner sweep out 1 million chemical reaction signal, the "line-by-line scanning, a small place to 0.5 Micron also all be swept into the reaction a 1 million are not leaking. " From the same point, the bio-chip is the" using electronic methods of production, the use of biological material "technology. Both different places is because the material used different functionality. Bio-chip original intention originally produced in or accompanied by the human genome project. "The original purpose of the human genome project is to understand why humans have cancer," Yang said, "but even in the plan is complete, the humanity is still no way to solve the root causes of cancer, from disease than the human genome project imagine more complex. "At this point, the bio-chip proposal becomes a powerful tool of pathology. The current foreign medical bio-chip application mainly on cancer and drug research. Bio-chip from the 1990s began to develop, always belongs to the cutting-edge, participated in the human genome in China is not far behind in this regard, there have been many studies of bio-chip manufacturers and research institutions, and at the international level have a certain impact. Maximum use is disease detection "biochip future is the same as computer chip-scale use." Yang Wei: Ping said, he called the bio-chip will be indispensable platform, currently only in its early stages. Because chip classification according to the test object and, therefore, have many different species. "Detection of protein chip is placed on the protein on a template, such as antibodies and antigens, enzymes and other proteins, is there a way to detect objects for proteins is also called protein chips. DNA chip is mainly used for the detection of nucleic acids, DNA, RNA, a small RNA, and so on, small-molecule microarrays are special, is some small chemicals such as antibiotics, pesticides, in food safety is very important because its molecules are very small, but are not part of the protein, so is the object under test. "Yang Wei: Ping on road. The mean Sung, biochip will according to the different needs on different materials, but is currently the largest bio-chip, a purpose or disease detection. Yang Hongbo says, biochip in agriculture such as diverted, GM, breeds, and other areas of great development prospects, similarly, in the field of public health and food safety areas have great development space. At present inCountries, such as Tsinghua University, and so several units of the Office of the US Office of biological and Nankai University, Tianjin biochip co., Ltd belongs to the domestic top bio chip company. China's main research and development of the bio-chip power concentrated in the joint enterprise of colleges and universities. "China's bio-chip, it should be successful. " Yang Hongbo says, in the industrialization of the United States are on the road, the first mastered the most original intellectual property," but we can develop other aspects of intellectual property rights, such as each different germs to separate out intellectual property rights, so that we can and foreign exchange. " Topic author/reporter gold Yu ■ Awakening Patch microarray biochips concepts taken from the integrated concept, electronic chip means big things into small things. Current common biological detection are great products, great reagents. Shrink, become very small things, like e-materials, bio-materials for integration into biochips. Chip so-called lab laboratory is a function of the integration. In general the lab, testing, analysis, etc. are divided into different steps, chip laboratories is put all the steps to get together, is also visible, just put these features to microfilm to a small platforms, biological detection of three major steps in the sample processing, bio-reaction, reaction of detection by different machines to do before the results of the laboratory of the chip is to these three steps condense into a platform for users who do not need to know the intermediate steps, is a miniature of the automated process. This is currently the world is the main way, China is no backward. ■ Boao dialogues biological Dr. Yang Wei: market demand-driven biological chip technology reporters: bio-chip should be on the basis of many disciplines? Yang Wei: Ping: a synthesis of many disciplines, optical, mechanical, electrical, biology, chemistry, information, primarily micro-processing technology. Microelectronics technology is the earliest prototypes that you want to do on the chip in a wide variety of slots, small response etc, this requires a micro-processing technology to realize, of course, does not require micro-processing technology can also implement, each inspection point is a test tube, the tube may be general, in millilitres, chip inside it is satisfied that the lift. More complex than the microelectronic technology, micro-electronics technology has only done a few transistors, semi-conductors, relatively mature, but only in the physical realm, but the bio-chip inside biological reactions. In addition to the micro-processing technology, also without such as chemistry, life sciences and other disciplines. Journalists: our Government seems to attach considerable importance to biochip? Yang Wei: Ping: Yes. Bio-chip this field is new in the last century, after the mid-1990s. The development of our country and not backward. Biochip industrialization and computer ratio or a small remnant, but has already begun in many areas of application, such as in food safety testing, like eggs, pork has no pathogenic bacteria, and the like small molecules are used to detect have antibiotic residues, etc. In diagnosis we already have, such as pathogenic microorganisms, autoimmune diseases, etc. But most of the major or research areas. Reporter: biochip likely as computer chips like suddenly appeared in ordinary life? Yang Wei: Ping: electronic chip may not immediately, it has 40 years of development, is a slow process. In the current development of bio-chip, technically there difficult, how to add a single index into multiple indicators, in opening up new product launched on, will have a lot of difficulties, but these difficulties do not is not resolved, the demand in the market, will gradually solved, but now also in its early stages. Multiple parameters at the same time, causing the rise in the cost, because the one-way detection, ordinary detection at a much lower cost, more of the indicators in the General test, you will add a lot of cost, as an emerging technology, especially in hospitals, diagnostic market, our acceptance and awareness of the need for a process. However I believe that as the needs increase, you will gradually accept multiple parameters, so that people on disease surveillance and control more accurate.